aspirin and age related macular degeneration; the possible relationship
نویسندگان
چکیده
800x600 age-related macular degeneration (amd) is becoming the leading cause of blindness in developed countries. the exact etiology and pathophysiology of amd is still unclear. a number of risk factors of amd have been recognized, such as cigarette smoking, a family history of amd and being caucasian. on the other hand, aspirin is a widespread medication, which is thought to be associated with the prevalence or the survival of myocardial infarction and cancers. however, the evidence from the epidemiological studies has been contradictory and no persuasive conclusions have been made. several problems, such as the parameters of aspirin use, the inclusion and exclusion of the participants and the required long-term follow-up, made it hard to conclude a definite relationship between aspirin use and amd. aspirin, as an anti-inflammatory agent, could prevent the inflammation and decrease the inflammatory damage, and might act as a deterrent for the progression of amd. however, aspirin is an anticoagulant which might increase the risk of ocular hemorrhage in amd patients. decades ago, the use of aspirin was reported associated with decreased rates of cnv among amd patients nevertheless recently, the association between aspirin use and increased risk of neovascular amd was identified. therefore, these current results should be challenged and acknowledged by well-designed, large-scale and long term follow-up studies. a consultation might be needed when aspirin is used in the neovascular amd patients. normal 0 false false false en-us x-none ar-sa to download this article online, scan this qr code with your smartphone
منابع مشابه
Aspirin and Age Related Macular Degeneration; the Possible Relationship
Age-related macular degeneration (AMD) is becoming the leading cause of blindness in developed countries. The exact etiology and pathophysiology of AMD is still unclear. A number of risk factors of AMD have been recognized, such as cigarette smoking, a family history of AMD and being Caucasian. On the other hand, aspirin is a widespread medication, which is thought to be associated with the pre...
متن کاملRelationship of Aspirin Use With Age-Related Macular Degeneration
I n their prospective population-based cohort study of 2389 patients in the Blue Mountains region in Australia, Liew and colleagues report on the association of long-term use of low-dose aspirin and age-related macular degeneration (AMD), the leading cause of blindness in Western countries. The principal finding is that regular aspirin use is associated with an approximately 2.5fold greater ris...
متن کاملthe genetics of age-related macular degeneration
age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...
متن کاملThe association of aspirin use with age-related macular degeneration.
OBJECTIVE To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. METHODS A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed...
متن کاملLong-term use of aspirin and age-related macular degeneration.
CONTEXT Aspirin is widely used for relief of pain and for cardioprotective effects. Its use is of concern to ophthalmologists when ocular surgery is being considered and also in the presence of age-related macular degeneration (AMD). OBJECTIVE To examine the association of regular aspirin use with incidence of AMD. DESIGN, SETTING, AND PARTICIPANTS The Beaver Dam Eye Study, a longitudinal p...
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عنوان ژورنال:
medical hypothesis, discovery and innovation ophthalmology journalجلد ۲، شماره ۳، صفحات ۵۹-۰
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